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Kevin

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Posts: 10
Reply with quote  #1 
Hello all,

I'm doubting that I'm get any good news on my question, but I figured it doesn't hurt to ask.

I'm hoping that, in time, stem cell research will catch up and provide a cure for both hyperacusis and tinnitus.  I have Googled this but have not seen anything all that is promising... that is recent.

Does anyone know where science is in terms of stem cell treatment for tinnitus and hyperacusis?

Thank you,

Kevin
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briann

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Posts: 141
Reply with quote  #2 
Nothing that soon unfortunately. And it's tough to tell which of these treatments will help with hyperacusis.

Here is an article on hearing restoration that was posted on the hyperacusis research Facebook page,

http://www.the-scientist.com/?articles.view/articleNo/43797/title/Hurdles-for-Hearing-Restoration/

There was also an article on using neurotrophins for hidden hearing loss in scientific american. I'm linking to some key points since the article must be purchased. But I do recommend reading the article.

http://hyperacusisfocus.org/2015/09/12/hidden-hearing-loss-and-neurotrophins-a-potential-hyperacusis-treatment/

And then there is research into medications for tinnitus and hearing loss which may or may not impact hyperacusis symptoms,

http://www.enttoday.org/article/drug-trials-for-hearing-loss-tinnitus-therapies-show-promise/
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Kevin

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Posts: 10
Reply with quote  #3 
Thanks Briann for the response.  I have a mixture of hope and despair after reading what I could in the free articles.  I guess I'll just have to wait to see what, if anything, comes from the research.

Thanks for taking the time to share that information.  [smile]

Kevin
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dave2

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Posts: 96
Reply with quote  #4 

Kevin,

There is a stem cell clinic in Bangkok performing treatment for inner ear disorders, but it is expensive ($25,000 range) and as yet untried by someone with hyperacusis. Several people have tried it for hearing loss and tinnitus and reported good results. So it is POSSIBLE it could help hyperacusis but we don't know because nobody has tried.

So, for someone with the money to spend and willing to take a chance, it is available now. Here is the link to the clinic:

http://ihplus.com/

There is EXTENSIVE information posted by one patient on his experience there:

https://www.tinnitustalk.com/threads/my-trip-to-bangkok-stem-cell-treatment-journal.1884/

Also, pages 7-9 of this newsletter discuss two additional patients who had similar treatment (Chloe from California and Francis from Australia):

http://www.c-a-network.com/pdfs/240186%20SHHH.pdf

Clearly this course of action would be only for the brave who have a lot of money and can manage a long airplane flight. And willing to take the chance it may not help.

But I think it is good to know that there actually is something that can be tried now for someone meeting these criteria. The safety aspect seems reasonable, I think there are always risks, but the treatment is comparable to what the 100+ stem cell clinics in the United States are doing now for countless patients (but none of them are doing it specifically for inner ear disorders like the clinic in Bangkok).

Dave


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Rob

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Posts: 4,049
Reply with quote  #5 
Hyperacusis is treatable.  Tinnitus is manageable.  The stem cell clinic in Bangkok doesn't perform treatment.  It is a sham.  The person who went there wasn't brave.  He was desperate.  My two cents. 

Rob

 

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Kevin

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Posts: 10
Reply with quote  #6 
Dave,

Thank you for the information, I really do appreciate it.  I really enjoyed reading the benefits of the person who went to Bangkok.  It gives me hope that, at the very least, stem cell therapy can significantly reduce tinnitus.  I believe it would help hyperacusis as well.  As the article says, it's just a matter of finding the damaged cells and getting the stem cells to realize they are in need of repair.

Thank you again for sharing.  [smile]

Kevin
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dave2

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Posts: 96
Reply with quote  #7 
Kevin,

Glad you found it interesting! It gives me hope for the future too.

This article from February 2016, about a former police officer who lives near me, is slightly off topic in terms of hyperacusis and tinnitus, but I found it very eye-opening (no pun intended) as to how the pace of development of stem cell therapies could be accelerating at the clinical level, not just with mice and rats:

http://www.baltimoresun.com/health/bs-hs-stem-cells-for-eyes-20160201-story.html

I hope that we will be reading articles like this for H and T soon! The trick is that the inner ear is more difficult to access than the eye from a stem cell perspective. But they are making progress in figuring out how to do intra-tympanic injections toward that end. The StemCells21 approach right now is one of brute force - send hundreds of millions of stem cells into the bloodstream so at least some of them reach the cochlea. The silver lining is that if there was something else wrong, like a stiff knee, that could possibly improve at the same time.

Dave
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dave2

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Posts: 96
Reply with quote  #8 

Interesting update presentation on the first clinical trial in the United States to use stem cells for hearing loss. Here is an excerpt that sounds hopeful:

" Thus far, 9 patients have received IV infusions of their own cord blood stem cells (autologous) with no adverse events. The anticipated completion date is February, 2017. While Dr. Baumgartner is not allowed to discuss the results until the final patient is treated, “I can say the results from that Duke paper is something we are encouraged by.” When asked if donor cord blood might next be investigated, Dr. Baumgartner expressed that people are interested in using matched donor cord blood, but that “it’s easier to convince the FDA to use a 6 week’s old own cord blood because it’s considered safer.” "


So, hopefully today for children with hearing loss with their own cord stem cells, and tomorrow for everyone with hyperacusis (and other inner ear problems) with donor cord stem cells.


PowerPoint:

https://www.tinnitustalk.com/attachments/advances-in-stem-cell-therapy-for-hearing-loss-florida-hospital-for-children-pdf.10077/


Additional comments by the presenter, Dr. Baumgartner:

http://www.cryo-cell.com/Blog/March/Umbilical-Cord-Blood-Stem-Cells-to-Treat-Acquired


Some comments on specific slides:

https://www.tinnitustalk.com/threads/my-trip-to-bangkok-stem-cell-treatment-comments.1891/page-10#post-176992

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dave2

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Posts: 96
Reply with quote  #9 
Here is something new on stem cell therapy. To my knowledge, this is the first time that intra-tympanic stem cell injections are offered:

http://stemcells21.com/stem-cell-treatments/hearing-loss-stem-cell-treatment-2/

Seems rather groundbreaking. It is advertised for tinnitus and hearing loss. I wonder if it would be effective for hyperacusis too.
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kuhnstefanie

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Posts: 15
Reply with quote  #10 
Thanks for the information you have shared guys.. the daughter of my cousin has hyperacusis issue also.
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dave2

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Posts: 96
Reply with quote  #11 
Interesting developments from a new company based in Massachusetts called Frequency Therapeutics which plans to start inner ear stem cell therapy trials in human patients next year. Maybe their approach will help hyperacusis and tinnitus in addition to hearing loss.

https://endpts.com/another-langer-backed-biotech-breaks-out-of-stealth-mode-aims-for-the-clinic-with-hearing-loss-therapy/
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