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TallDude

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Posts: 162
Reply with quote  #1 
Source: https://www.sciencedirect.com/science/article/pii/S0014579315007309#b0245

"The main effect of the MOC efferent innervation is to inhibit cochlear responses by decreasing the gain of the OHC amplifier. This effect is observed as a reduction in basilar membrane motion, and also as a transient loss in auditory nerve sensitivity to sound [49]."

AND

Source: https://www.scopus.com/record/display.uri?eid=2-s2.0-33750613317&origin=inward&txGid=ccf4df388b1953e9d3c7cf62268d9b8d

"A variety of data indicate that MOC efferents help to reduce acoustic trauma and lessen the masking of transients by background noise; for instance, they aid in speech comprehension in noise."

sounds familiar doesn't it?

AND:

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772446/

"Second, it may be that the LOC system, either its cholinergic or GABAergic components, underlie the protective effects and that increased MOC reflex strength (as assayed by DPOAE post-onset adaptation) correlates with increased LOC activity. Indeed, indirect evidence suggests that high MOC feedback activity may be correlated with high LOC feedback activity, i.e., that a high MOC reflex strength is indicative of a generally hyper-reflexic state."

Again we end up with "GABA", the only supplement that seemed to help me...

BUT

"A variety of data indicate that MOC efferents help to reduce acoustic trauma"

That makes me worry...



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TallDude

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Posts: 162
Reply with quote  #2 
Maybe interesting for the TRT fans:

I came across a study where they exposed animals (i think rats) to broadband noise for longer periods and next did MOC reflex tests and guess what: this seemed to increase the MOC reflex...

Unfortunally can't find the study anymore...too many webpages in my browser ;-)

MAYBE TRT DOES REALLY WORK! LOL

I'm confused. Gonna drink me a bottle of wine seems to help too.



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TallDude

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Posts: 162
Reply with quote  #3 

"Hyperactivity in the medial olivocochlear efferent system is a common feature of tinnitus and hyperacusis in humans"

MOC = Medial Olivo Cochlear

"These findings are intriguing, and they raise many exciting scientific questions, which are experimentally tractable and may have important clinical implications. For example, if enhanced MOC-mediated suppression of cochlear activity contributes to tinnitus and/or hyperacusis, then selective reductions of MOC pathway activity may prove useful in ameliorating patients' symptoms."


Source: https://journals.physiology.org/doi/full/10.1152/jn.00948.2014





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HST

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Posts: 35
Reply with quote  #4 
so what is the news on it in pain hyperacusis? the mecanizem of moc ,mbd,ic , main ac and more then 4 other hearring brain structures for each side if ear can be damage by there functions in pain hyperacusis..its not new at all.
there no drug yet.
no relief from the killing and devastating pains
why theres no form of medical test like mri that dont good for hyperacusis l -fmri or meg unige test to us?
dide they can observe and test nerve damage or just brsin damage?
i didnt see any tests for afferent or effernt damage!
there was studies and research but they didnt say with
whst Dedicated devices and what data have been put into i those sevices. The medical doctors in the world suffers so much from no understanding the terrible disease, why are there no ear neurologists who understand the possible mechanism of injury? Only in Corona are they investing! If there were investors from 1/10 time and money again we would have recovered. It's a shame for everyone. From Trump to I do not know who.
why its all just in the searchers field,before 5 years there was astudy by propesor salvi if brrain and nerve damage of the hearing system?why irs not in the hospitals yet!!!!
why its hasent in the medicine filed in the hispitals for each h person or ht person?
its fastreiting for it self..
its harmless state we cant live with this state!!!
help us!!!!!! the trt dont help us!!
cbt it no useless for pain.. we cant goes out without get pains and pains....

__________________
HYPER IS ATOM PAIN
TINITUS IS  NO PAiN BUT FANTOM
I am ht
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